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Prednisone 40 MG not working effectively to put me in remission


Thu, November 29, 2018 3:41 PM

Hello, I have been going through a bad UC flare up since September and have been taking Prednisone (first-time ever) for 6 weeks now.  Past 2 weeks the dosage has been at 40 MG.  While it has helped, I am still experiencing urgency and frequent BM (10 times a day).  The only thing that Prednisone has helped me with is that I have little to no blood in stools and I have semi-formed to formed stools (no liquid stools like before).

My GI doctor put me on 6-MP but I decided to get a 2nd opinion from another GI who felt that since I'm not in remission yet I should not take 6-MP and he chose to have me continue on Prednisone for 2 more weeks at 40 MG.  My upcoming appointment is on Monday and I feel like the Prednisone has not really put me in remission.

What would be the next treatment in line?  Biologics, Entyvio?
I read that most severe UC patients respond well to Prednisone.  

FPO skapoor2
Joined Nov 29, 2018

Fri, November 30, 2018 8:14 AM

Reply posted for skapoor2.

Prednisone was the only thing that worked for me.  None of the other drugs did a thing.  I eventually and the jpouch surgery and that worked fairly well but then I developed Crohn s.  Now I’m on biologics I had remicade, now on entyvio.  I don’t think they work worth a darn, buy my doctor disagrees 

FPO charbs
Joined Oct 31, 2016

Thu, November 29, 2018 4:41 PM

Reply posted for skapoor2.

It looks like the 6mp or prednisone is not working, so yes, biologics is most likely the next route. If you do biologics, you are probably going to start with either Remicade or Humira. I have crohn's and I am on Remicade, and it has been working perfectly, I have no symptoms at all. I hope you feel better!

FPO andrew 2012
Joined Dec 13, 2018

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