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Scientists linked missing gut microbe to UC, opening door to possible new treatment


Tue, October 13, 2020 10:40 AM

Is anyone else following a research clinical trial? Lack of gut Ruminococcaceae microbe prevents bile acid conversion leading to inflamation and sores in colon. Fascinating.

Quote: 'To get to this point, the team is now conducting a clinical trial to discover whether an acid supplement can help people with ulcerative colitis.'

Quote: “We hope it also leads to our being able to treat it with a naturally produced metabolite that’s already present in high amounts in a healthy gut.” – 

https://www.medicalnewstoday.com/articles/gut-microbes-could-be-key-to-treating-ulcerative-colitis

FPO huggybear
Joined Oct 13, 2020

Tue, January 19, 2021 8:56 PM

Reply posted for huggybear.

Apparently there's a certain kind of seaweed / kelp that may help increases the Ruminococaceae, Laminaria Japonica:


0 Seaweeds can be subdivided into three categories based on their pigmentation; Rhodophyta (red seaweed), Chlorophyta (green seaweed) and Phaeophyta (brown seaweed).99 Differences in composition and structure of the polysaccharides present in these seaweeds are also evident. Brown seaweed is of particular interest as it possesses polysaccharides such as fucoidan, laminarin and alginate.101 Fucoidans comprise a class of fucose-rich sulfated polysaccharides often located in the cell walls of brown macroalgae. It is suggested that fucoidans with differing structures may impact the gut in a variety of ways. For example, a study carried out by Shang et al.,102 established that fucoidans isolated from Ascophyllum nodosum (FuA) and Laminaria japonica (FuL) had positive but slightly differing effects on the murine gut microbiota due to their structural differences. FuA has a type I back-bone structure whereas FuL has a type II structure. FuL markedly increased the levels of Ruminococcaceae while FuA enhanced Lactobacillus, Anaeroplasma and Thalassospira.





https://en.wikipedia.org/wiki/Saccharina_japonica

(It says Laminaria Japonica is a synonym in the box on the right)

I haven't tried this yet, but I took a note of it a while back.  Apparently it's also good for the intestinal barrier (or at least the extract is):

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567143/

FPO NorthernLights
Joined Jan 18, 2021

Sat, December 05, 2020 7:58 AM

Reply posted for huggybear.

Quote: In this study the investigators will investigate if ursodeoxycholic acid (UDCA) may reduce inflammatory markers and improve quality of life (as assessed by validate survey) in those subjects with active antibiotic refractory or antibiotic dependent pouchitis.

From: https://clinicaltrials.gov/ct2/show/NCT03724175

They're testing if drug ursodiol (ursodeoxycholic acid, UDCA) helps.

FPO RistoJ
Joined Dec 1, 2020

Fri, November 27, 2020 9:39 PM

Reply posted for scbrac.

Thanks for posting. I read that a doctor is investigating the antiinflammatory effects of ursodeoxycholic acid oral supplements, currently used for treating gallstones. There are some articles on the web: https://journals.physiology.org/doi/abs/10.1152/ajpgi.00163.2019  - Ursodeoxycholic acid: a promising therapeutic target for inflammatory bowel diseases?
Did contacting her help in any way?

FPO huggybear
Joined Oct 13, 2020

Wed, November 18, 2020 8:47 PM

Reply posted for scbrac.

Great! Any luck with probiotics? I'm still hoping for an alternative to mesalamine.
I think the research will be going on for several years.
another interesting article on UC and probiotics https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033537/   Visbiome (formerly VSL#3) has had some clinical success...

FPO huggybear
Joined Oct 13, 2020

Mon, November 02, 2020 8:28 AM

Reply posted for huggybear.

I just read about this study too.  Intereting.  I emailed th Doctor who is conduction the study.  Lets see what she says.  In th meantime, Iam looking for probiotics that contain Ruminococcaeae.  Does anyone have any suggestions as accordng to ths study, this coudl be the cause of UC (a lack of this bacteria that is normally producee by the liver). Thanks!

FPO scbrac
Joined Nov 2, 2020

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