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Zeposia question

Fri, March 17, 2023 1:54 PM

My son is a college student and was diagnosed with UC in 2018.  He has been taking Mesalamine since being diagnosed with no issues.   However, his colonoscopy in December 2022 revealed some inflammation and recent calprotectin was in the 400s.  His doctor is recommending he switch to Zeposia.  I am curious about this new medication and if anyone has taken it--side effects, ect OR is there an alternative.  His doctor says his UC is still considered mild.  Thank you!

FPO amr1016
Joined Mar 17, 2023

Fri, June 23, 2023 7:35 AM

Reply posted for annastark.

Side effects
in clinical studies 

When starting a treatment, it’s important to understand what side effects are possible. These are some of the side effects reported by people taking ZEPOSIA during both of the clinical studies.

Possible serious side effects

  • Progressive multifocal leukoencephalopathy (PML):ZEPOSIA can increase your risk for PML, which is a rare brain infection that gets worse over days to weeks, and usually leads to death or severe disability
  • ZEPOSIA may cause your heart rate to temporarily slow down (also known as bradyarrhythmia) when you start taking ZEPOSIA—especially during the first 8 days. Symptoms include dizziness, lightheadedness, feeling like your heart is beating slowly or skipping beats, shortness of breath, confusion, chest pain, or tiredness
  • Liver problems: Symptoms include unexplained nausea, vomiting, stomach area (abdominal) pain, tiredness, loss of appetite, yellowing of the whites of your eyes or skin, or 
    FPO gameofcrohns42
    Joined May 11, 2023

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