Community Forum

Have a question, or want to share your own tips and experiences? Join the discussion in the community forum. You must be registered to participate. Our forums are moderated by Crohn's & Colitis Foundation staff to facilitate a safe environment.

Humira and possible drug induced Lupus


Mon, July 09, 2018 7:27 PM

Has anyone developed drug induced Lupus with Humira?  I have been on it for 7 years with absolutely no issues and am in clinical remission and feeling great except for these episodes of extreme lethargy, nervousness(anxiety) feelings, and a general weird feeling in my head.  It has only happened recently with injections and doesnt happen every time.  Blood work shows a positive ANA with high Histone antibodies.  

FPO ljkclark740
Joined Jul 9, 2018

Mon, January 28, 2019 7:57 PM

Reply posted for ljkclark740.

This is second hand information at best.  I have Crohn's, and my two gastroenterologists have been urging me to take Humira.  I casually asked my oropedist if he had any patients of his had had Humira treatments, and he replied that two of them developed Lupus.

FPO astinchecum
Joined Feb 27, 2017

Fri, December 14, 2018 9:09 PM

Reply posted for Jhawks.

Hi Jhawks,

As someone whos felt the same way I can empathize.  Have they tried Remicade with you yet?

Ann

FPO Annlo65
Joined Dec 14, 2018

Tue, December 04, 2018 5:08 PM

Reply posted for ljkclark740.

I developed lupus after 12 years of remicade.  I switched to entyvio but I also have severe psoriasis and entyvio did nothing for psoriasis.  I eventually was switched to Stelara which seems to be doing a good job on my Crohn’s disease and psoriasis.

FPO Roadking305
Joined Dec 4, 2018

Wed, September 26, 2018 7:45 PM

Reply posted for ljkclark740.

I’ve been on Humira about 5 years and I started having bouts of Nausea with violent heaving day or two after injection.  Lately my feet and limbs hurt all day everyday.  I’ve fought extremely overwhelming fatigue for about 6 months.  Even my butt cheeks are having arthritis like pains.  My fingers and toes hurt my arms hurt my head has shooting pains.  I want OFF there’s got to be something else.😢

FPO Jhawks
Joined Sep 26, 2018

Sat, August 25, 2018 10:04 AM

Reply posted for cyndenator.

I don't know about drug induced lupus but I do know for past 6 years my ana count has been high off and on... went to rheumetologist and they called it non specific autoimmune disorder. Dec 2016 my abdomen pains were so bad I had a ct scan showing possible crohns.  finally diagnosed Jan 2017 by a gastroentologist and when I talked to my rheumitologist she said that crohns would cause all symptoms i had been having so that is my autoimmune disorder.  I think people forget crohns is an autoimmune disease and can create lupus like symptoms.  I have read material on humira induced lupus but are they taking into account that your ana has not been tested prior to the humira when flareups occured? after azathiprine (put me in hospital with pancreatitis) entocrt for three months with no help and a terminal illeum removal and resection last november I am now prescribed humira due to a ct scan showing continued thickening of intestine from surgery site outward causing pain and diahrrea again.  I guess in a couple weeks when I finally get the prescription approved and made affordable I will begin and can tell you whether my lupus type symptom escalate or reduce.  My rheumatologist says it humira is only resolution for me to control autoimmune disorder so.... odd. 
no one would call what I have as lupus even though my mothers sister was diagnosed with lupus.   keep me updated.  

FPO cyndenator
Joined Jul 11, 2018

Related Topics

Biologic vs. Imuran
Author Image jrichins
Joined Feb 10, 2018

My 18 y/o with Crohns is currently on Imuran (for ....

read more

Which med to try first??
Author Image justmarie17
Joined Jan 17, 2019

Hi Everyone, This is my first post. I've manag....

read more

Less Painful Version of H...
Author Image Mattison30
Joined Nov 14, 2018

I recently read about Citrate Free Humira. It is s....

read more