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Weight gain causing Remicade to lose effectiveness? Desperate for answers.

Sun, November 24, 2019 5:25 PM

Does anyone know or where I can find info on Remicade dosage effectiveness in relation to weight gain? On Remicade 16yrs (for fistula), started at 5mg, but increased to 10mg every 4wks in the 1st yr. Started having symptoms (similar to before Remicade, in behind) a few yrs ago, when weight increased over 100 lbs (102). As weight increased so did symptoms severity/frequency, breifly disappeared when lost to 92-97 lbs. Regained--back again. Worsening as I gained to 123-24 lbs. Dr refuses to listen because high Remicade levels and no antibodies. I'm screaming and crying in pain everyday and losing hope that I'll ever feel better. Wavering between fighting and holding on to defeated. Im worried Im going to have a heart attack from the stress. :(

Rayne9
Joined Nov 24, 2019

Fri, April 22, 2022 2:44 AM

Reply posted for Rayne9.

Abstract

Background: Infliximab (IFX) is used in active Crohn's disease for induction and maintenance of remission. There are scanty data on weight gain in IBD-patients under anti-TNF treatment. We investigated changes in weight and blood chemistry in anti-TNF-naïve Crohn's disease patients during their first course of IFX. Slope Unblocked will undoubtedly improve your hand-eye coordination. Your ball's speed will progressively rise as you begin the quest.
Methods: Retrospective analysis of 110 patients (77 men, 33 women) aged 34 years (range 14-73), 54 with luminal and 56 with fistulising disease, given at least 3 infusions of IFX (range 3-11). Data regarding body weight, height, C-reactive protein (CRP), haemoglobin and S-albumin at baseline, before the third infusion, at three months and at 12 months were collected.

Results: At 6 weeks, 65 (59%) increased in weight, 73% and 76% at three and 12 months, respectively. There was an increase in median weight (1.7 kg, IQR = 3.1 kg) and BMI (0.5 kg/m2, IQR = 1.2 kg/m2) at 6 weeks, which persisted at three and 12 months (all p < .001). There was no difference between men and women. Young patients, patients with underweight or fistulising disease increased most in weight. Disease activity assessed by PGA and SES-CD decreased at all time points (p < .05). Increases in weight and BMI correlated with an increase in serum albumin and a decrease in CRP.

Conclusion: Approximately 60% of Crohn's disease patients experience weight gain within the first six weeks of infliximab treatment. The weight increment correlates with improvements in inflammatory markers and disease activity. The causes of weight gain may be related to treatment induced metabolic changes and reduced inflammatory burden.

radley112
Joined Feb 16, 2022

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